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KMID : 1036420170100020045
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대한치의학회 영문학회지
2017 Volume.10 No. 2 p.45 ~ p.52
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Calcium Signaling in Salivary Secretion
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Kim Jin-Man
Lee Sang-Woo
Park Kyung-Pyo
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Abstract
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Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca2+ plays a key role during the secretion of salivary glands. In this review, we introduce the diverse cellular components involved in the saliva secretion and related dynamic intracellular Ca2+ signals. Calcium acts as a critical second messenger for channel activation, protein translocation, and volume regulation, which are essential events for achieving the salivary secretion. In the secretory process, Ca2+ activates K+ and Cl? channels to transport water and electrolyte constituting whole saliva. We also focus on the Ca2+ signals from intracellular stores with discussion about detailed molecular mechanism underlying the generation of characteristic Ca2+ patterns. In particular, inositol triphosphate signal is a main trigger for inducing Ca2+ signals required for the salivary gland functions. The biphasic response of inositol triphosphate receptor and Ca2+ pumps generate a self-limiting pattern of Ca2+ efflux, resulting in Ca2+ oscillations. The regenerative Ca2+ oscillations have been detected in salivary gland cells, but the exact mechanism and function of the signals need to be elucidated. In future, we expect that further investigations will be performed toward better understanding of the spatiotemporal role of Ca2+signals in regulating salivary secretion.
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KEYWORD
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Calcium-activated chloride channels, Calcium oscillations, Calcium signaling, Inositol 1, 4, 5-trisphosphate receptors, Salivary glands, Salivation
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